NEGR1

Entrez Summary: N/A
UniProt Summary: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hinokiflavone 12μM R08 exp487	-1.77
Dorsomorphin 5μM R07 exp357	-1.75
42°C R08 exp539	1.7
Heregulin-B 44ng/ml R08 exp486	1.74
LY2090314 0.003μM R08 exp500 no dilution day6	1.77
Losmapimod 1μM R07 exp376	1.78
SGC0946 7μM R03 exp151	1.81
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.83
UM131593 0.2μM R03 exp106	1.89
MKC9989 10μM R03 exp133	2.23

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

feeding behavior
anchored component of membrane
locomotory behavior
positive regulation of neuron projection development
positive regulation of neuron differentiation
positive regulation of cell projection organization
positive regulation of neurogenesis
regulation of neuron projection development
cell-cell adhesion
positive regulation of nervous system development
positive regulation of cell development
behavior
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
regulation of nervous system development
cell adhesion
regulation of cell development
biological adhesion
positive regulation of cell differentiation
positive regulation of cellular component organization
positive regulation of developmental process
generation of neurons
neurogenesis
positive regulation of multicellular organismal process
regulation of cell differentiation
extracellular region