NR4A1

Entrez Summary: N/A
UniProt Summary: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. {ECO:0000250, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:22983157}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	-2.01
Pyridostatin 4μM R05 exp240	-1.99
LJH685 5μM R02 exp73	-1.73
2-Methoxyestradiol 0.55μM R07 exp310	1.75
Resveratrol 16μM R03 exp147	1.82

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-C4
Hormone recep

response to corticotropin-releasing hormone
cellular response to corticotropin-releasing hormone stimulus
endothelial cell chemotaxis
regulation of type B pancreatic cell proliferation
glucocorticoid receptor binding
cell migration involved in sprouting angiogenesis
blood vessel endothelial cell migration
cellular response to vascular endothelial growth factor stimulus
nuclear receptor activity
steroid hormone receptor activity
sprouting angiogenesis
endothelial cell migration
epithelial cell migration
epithelium migration
tissue migration
positive regulation of endothelial cell proliferation
fat cell differentiation
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
steroid hormone mediated signaling pathway
regulation of endothelial cell proliferation
intracellular receptor signaling pathway
hormone-mediated signaling pathway
ameboidal-type cell migration
transcription initiation from RNA polymerase II promoter
cellular response to steroid hormone stimulus
positive regulation of epithelial cell proliferation
transcription factor complex
cell chemotaxis
DNA-templated transcription, initiation
nuclear membrane
cellular response to peptide hormone stimulus
RNA polymerase II regulatory region sequence-specific DNA binding
angiogenesis
cellular response to peptide
response to steroid hormone
regulation of epithelial cell proliferation
response to peptide hormone
blood vessel morphogenesis
sequence-specific DNA binding