PLA2G15

Entrez Summary: N/A
UniProt Summary: Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3- phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl- sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508). {ECO:0000250|UniProtKB:Q8VEB4, ECO:0000269|PubMed:10092508, ECO:0000269|PubMed:11790796, ECO:0000269|PubMed:20410020, ECO:0000269|PubMed:23958596, ECO:0000269|PubMed:25727495}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Abhydrolase 6
LACT

phosphatidylethanolamine catabolic process
phosphatidylcholine catabolic process
calcium-independent phospholipase A2 activity
O-acyltransferase activity
glycerophospholipid catabolic process
lysophospholipase activity
phosphatidylethanolamine metabolic process
phospholipid catabolic process
glycerolipid catabolic process
phosphatidylcholine metabolic process
ceramide metabolic process
fatty acid catabolic process
phospholipid binding
monocarboxylic acid catabolic process
organophosphate catabolic process
sphingolipid metabolic process
ammonium ion metabolic process
cellular lipid catabolic process
membrane lipid metabolic process
lysosome
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
glycerophospholipid metabolic process
fatty acid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
small molecule catabolic process
monocarboxylic acid metabolic process
intracellular membrane-bounded organelle
cellular amide metabolic process
organophosphate metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
lipid metabolic process
extracellular space
small molecule metabolic process