RHOC

Entrez Summary: N/A
UniProt Summary: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. {ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:20974804}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

skeletal muscle satellite cell migration
cell division site
positive regulation of protein homooligomerization
establishment or maintenance of actin cytoskeleton polarity
establishment or maintenance of cytoskeleton polarity
regulation of protein homooligomerization
positive regulation of protein oligomerization
wound healing, spreading of cells
epiboly involved in wound healing
epiboly
stereocilium
regulation of protein oligomerization
apical junction assembly
morphogenesis of an epithelial sheet
positive regulation of stress fiber assembly
cleavage furrow
positive regulation of actin filament bundle assembly
actin filament bundle assembly
actin filament bundle organization
mitotic cytokinesis
positive regulation of lipase activity
Rho protein signal transduction
regulation of stress fiber assembly
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
cytoskeleton-dependent cytokinesis
regulation of lipase activity
cytokinesis
cell-cell junction assembly
cell cortex
cell-cell junction organization
regulation of cell shape
cell junction assembly
positive regulation of I-kappaB kinase/NF-kappaB signaling
establishment or maintenance of cell polarity
positive regulation of supramolecular fiber organization
cell junction organization
positive regulation of cytoskeleton organization
regulation of I-kappaB kinase/NF-kappaB signaling
actin filament organization