SAFB2

Entrez Summary: The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016].
UniProt Summary: Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SAP
RRM 1

Sertoli cell differentiation
regulation of androgen receptor signaling pathway
regulation of intracellular steroid hormone receptor signaling pathway
male gonad development
development of primary male sexual characteristics
regulation of mRNA processing
male sex differentiation
gonad development
development of primary sexual characteristics
sex differentiation
nuclear body
regulation of mRNA metabolic process
sequence-specific DNA binding
reproductive structure development
reproductive system development
developmental process involved in reproduction
epithelial cell differentiation
intracellular membrane-bounded organelle
identical protein binding
epithelium development
RNA binding
reproductive process
reproduction
tissue development