SLC9A3

Entrez Summary: The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016].
UniProt Summary: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction. {ECO:0000269|PubMed:26358773}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ1 0.06μM R08 exp531	-2.03
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.93
FBS-Wisent 0.1 R07 exp426	-1.87
FK-506 30μM R07 exp359	-1.86
BML-284 0.09μM R08 exp460	-1.84
Ibrutinib 1μM R07 exp372	-1.74
MLN-4924 0.2μM R00 exp21	-1.7
Sulforaphane 9μM R08 exp526 no dilution day6	1.96

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

potassium:proton antiporter activity
sodium:proton antiporter activity
sodium ion import across plasma membrane
brush border
brush border membrane
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
regulation of intracellular pH
PDZ domain binding
sodium ion transmembrane transport
regulation of cellular pH
import across plasma membrane
regulation of pH
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
proton transmembrane transport
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
anion transmembrane transport
apical plasma membrane
monovalent inorganic cation transport
inorganic cation transmembrane transport
anion transport
cation transmembrane transport
cell surface
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
import into cell
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cation transport
cellular homeostasis
ion transmembrane transport
chemical homeostasis
transmembrane transport