TMED5

Entrez Summary: N/A
UniProt Summary: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle- mediated retrograde transport. {ECO:0000269|PubMed:19948005}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
A-395 10μM R05 exp218	-1.79
PF-06409577 20μM R07 exp389	-1.77
IU1-C 25μM R04 exp183	1.77
Parthenolide 2.5μM R05 exp238	1.85
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	2.16

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Golgi ribbon formation
endoplasmic reticulum exit site
COPII-coated ER to Golgi transport vesicle
cis-Golgi network
endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum-Golgi intermediate compartment
Golgi organization
endoplasmic reticulum to Golgi vesicle-mediated transport
Golgi vesicle transport
endomembrane system organization
endoplasmic reticulum membrane
Golgi apparatus
intracellular protein transport
endoplasmic reticulum
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport