TNRC6C

Gene Information

Official Symbol: TNRC6C
Official Name: trinucleotide repeat containing adaptor 6C
Aliases and Previous Symbols: N/A
Entrez ID: 57690
UniProt: Q9HCJ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in RNA-mediated gene silencing by micro- RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4- NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:21984184, ECO:0000269|PubMed:21984185}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM131593 0.2μM R03 exp106	-2.24
L-74142 5μM R03 exp131	-1.82
MK-1775 0.32μM R02 exp75	-1.82
NFN1 0.4μM R03 exp99	-1.75
IU1-C 25μM R04 exp183	-1.73
RO-3307 4.7μM R02 exp80	-1.72
Zebularine 20μM R07 exp423	2.03

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8208
Expression level (log2 read counts): 5.59

Expression Distribution

Ago hook
UBA
M domain

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
regulation of translation, ncRNA-mediated
negative regulation of translation, ncRNA-mediated
miRNA mediated inhibition of translation
regulation of nuclear-transcribed mRNA poly(A) tail shortening
RISC complex
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Wnt signaling pathway, calcium modulating pathway
gene silencing by miRNA
positive regulation of mRNA catabolic process
regulation of megakaryocyte differentiation
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
positive regulation of mRNA metabolic process
P-body
gene silencing by RNA
negative regulation of translation
non-canonical Wnt signaling pathway
negative regulation of cellular amide metabolic process
gene silencing
regulation of mRNA catabolic process
regulation of myeloid cell differentiation
regulation of gene expression, epigenetic
regulation of mRNA metabolic process
regulation of translation
Wnt signaling pathway
cell-cell signaling by wnt
positive regulation of cellular catabolic process
regulation of cellular amide metabolic process
cell surface receptor signaling pathway involved in cell-cell signaling
positive regulation of catabolic process
regulation of hemopoiesis
posttranscriptional regulation of gene expression
regulation of cellular catabolic process
regulation of catabolic process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
cell-cell signaling
negative regulation of cellular macromolecule biosynthetic process