WBP4

Entrez Summary: N/A
UniProt Summary: Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex. {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:9724750}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 11μM R07 exp314	-1.8
Docetaxel 0.002μM R01 exp45	-1.75
A-196 10μM R03 exp114	-1.72
Lead acetate 2000μM R08 exp498 no dilution day6	1.7
Deguelin 0.15μM R05 exp209	1.71
Lead acetate 2000μM R08 exp497	1.73
Oligomycin-A 2μM R00 exp25	1.76
Calcium Ionophore 0.4μM R07 exp342	1.79
CB-5083 0.4μM R08 exp468	1.98
FK-506 30μM R07 exp359	2.05
RO-3307 4.7μM R02 exp80	2.05
Vemurafenib 6.6μM R08 exp434	2.08
Etoposide 1μM R00 exp19	2.35
Clomiphene 4.4μM R02 exp68	2.43
Etoposide 0.1μM R05 exp198	2.74
Latrunculin-B 10μM R07 exp374	2.83
Tozasertib 0.1μM R07 exp414	2.94
Genistein 15μM R07 exp360	2.98
MK2206 4μM R08 exp504	3.3

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

WW
zf-U1

proline-rich region binding
mRNA cis splicing, via spliceosome
U2-type precatalytic spliceosome
nucleic acid binding
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
zinc ion binding
RNA processing
RNA metabolic process
gene expression