ZFAND6

Entrez Summary: N/A
UniProt Summary: Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'- linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity). {ECO:0000250, ECO:0000269|PubMed:19285159, ECO:0000269|PubMed:21810480}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 11μM R07 exp314	1.72
MK2206 4μM R08 exp504	1.75
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.83
Rapamycin 1μM R00 exp29	1.98
I-BRD9 4μM R07 exp365	2.11
Mubritinib 0.2μM R02 exp65	2.13
Dimethyloxaloylglycine 100μM R05 exp229	2.19
Vinorelbine 0.001μM R05 exp249	2.56

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zf-AN1
zf-A20

polyubiquitin modification-dependent protein binding
establishment of protein localization to peroxisome
protein targeting to peroxisome
protein localization to peroxisome
peroxisomal transport
peroxisome organization
regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to tumor necrosis factor
response to tumor necrosis factor
protein targeting
establishment of protein localization to organelle
cellular component
protein localization to organelle
molecular function
zinc ion binding
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
intracellular protein transport
negative regulation of cell death
cellular response to cytokine stimulus
programmed cell death
cell death
response to cytokine
DNA binding
protein transport
intracellular transport
peptide transport
regulation of apoptotic process
regulation of programmed cell death
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
regulation of cell death
regulation of intracellular signal transduction
establishment of localization in cell
nitrogen compound transport