ZPBP

Entrez Summary: N/A
UniProt Summary: Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity). {ECO:0000250|UniProtKB:Q62522, ECO:0000269|PubMed:21911476}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
A-196 10μM R03 exp114	-1.83
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.71
LLY-284 2.6μM R06 exp291	1.72
Nocodazole 0.2μM R00 exp24	1.79
SB743921 0.001μM R05 exp244	2.06
Vinblastine 0.015μM R05 exp208	3.16

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acrosomal membrane
binding of sperm to zona pellucida
sperm-egg recognition
cell-cell recognition
single fertilization
fertilization
cell recognition
sexual reproduction
multi-organism reproductive process
reproductive process
reproduction
extracellular region