ACSL3
Gene Information
- Official Symbol: ACSL3
- Official Name: acyl-CoA synthetase long chain family member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 2181
- UniProt: O95573
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). {ECO:0000250, ECO:0000269|PubMed:18003621}.
Pfam Domains GO Terms
Pfam Domains
| AMP-binding |
GO Terms
| positive regulation of phosphatidylcholine biosynthetic process |
| positive regulation of Golgi to plasma membrane protein transport |
| regulation of phosphatidylcholine biosynthetic process |
| decanoate-CoA ligase activity |
| regulation of Golgi to plasma membrane protein transport |
| lipid import into cell |
| long-chain fatty acid import into cell |
| very-low-density lipoprotein particle assembly |
| positive regulation of phospholipid biosynthetic process |
| long-chain fatty acid-CoA ligase activity |
| acyl-CoA ligase activity |
| regulation of phospholipid biosynthetic process |
| long-chain fatty-acyl-CoA biosynthetic process |
| long-chain fatty-acyl-CoA metabolic process |
| plasma lipoprotein particle assembly |
| protein-lipid complex assembly |
| fatty-acyl-CoA biosynthetic process |
| fatty-acyl-CoA metabolic process |
| plasma lipoprotein particle organization |
| acyl-CoA biosynthetic process |
| thioester biosynthetic process |
| positive regulation of phospholipid metabolic process |
| protein-lipid complex subunit organization |
| positive regulation of protein localization to plasma membrane |
| peroxisomal membrane |
| long-chain fatty acid transport |
| purine nucleoside bisphosphate biosynthetic process |
| nucleoside bisphosphate biosynthetic process |
| ribonucleoside bisphosphate biosynthetic process |
| positive regulation of protein localization to cell periphery |
| regulation of plasma lipoprotein particle levels |
| fatty acid transport |
| positive regulation of lipid biosynthetic process |
| lipid droplet |
| regulation of phospholipid metabolic process |
| fatty acid derivative biosynthetic process |
| regulation of protein localization to plasma membrane |
| acyl-CoA metabolic process |
| thioester metabolic process |
| regulation of protein localization to cell periphery |
| long-chain fatty acid metabolic process |
| fatty acid biosynthetic process |
| positive regulation of protein localization to membrane |
| nucleoside bisphosphate metabolic process |
| ribonucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| monocarboxylic acid transport |
| coenzyme biosynthetic process |
| positive regulation of lipid metabolic process |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| mitochondrial outer membrane |
| fatty acid derivative metabolic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| sulfur compound biosynthetic process |
| monocarboxylic acid biosynthetic process |
| regulation of lipid biosynthetic process |
| regulation of protein localization to membrane |
| cofactor biosynthetic process |
| response to nutrient |
| protein domain specific binding |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| carboxylic acid transport |
| organic acid transport |
| lipid transport |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| purine ribonucleotide metabolic process |
| lipid localization |
| fatty acid metabolic process |
| positive regulation of cellular protein localization |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| extracellular structure organization |
| regulation of lipid metabolic process |
| positive regulation of protein transport |
| positive regulation of secretion |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic anion transport |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| response to nutrient levels |
| amide biosynthetic process |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| organophosphate biosynthetic process |
| regulation of cellular protein localization |
| nucleobase-containing small molecule metabolic process |
| regulation of vesicle-mediated transport |
| lipid biosynthetic process |
| anion transport |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| import into cell |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| head development |
| cellular amide metabolic process |
| regulation of secretion |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| regulation of cellular localization |
| response to organic cyclic compound |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| central nervous system development |
| Golgi apparatus |
| positive regulation of transport |
| oxoacid metabolic process |
| endoplasmic reticulum |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| regulation of protein localization |
| nucleobase-containing compound biosynthetic process |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| lipid metabolic process |
| organic cyclic compound biosynthetic process |
| ion transport |
| organonitrogen compound biosynthetic process |
| ATP binding |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of cellular biosynthetic process |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 58/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 1/28 |
| bone | 4/26 |
| breast | 0/33 |
| central nervous system | 4/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 2/21 |
| liver | 2/20 |
| lung | 7/75 |
| lymphocyte | 1/16 |
| ovary | 4/26 |
| pancreas | 3/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 2/9 |
| thyroid | 1/2 |
| upper aerodigestive | 4/22 |
| urinary tract | 3/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15308
- Expression level (log2 read counts): 7.05
Expression Distribution
ACSL3 Expression in NALM6 Cells: 7.05
