ACSL6

Entrez Summary: The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011].
UniProt Summary: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

decanoate-CoA ligase activity
long-chain fatty acid-CoA ligase activity
acyl-CoA ligase activity
long-chain fatty-acyl-CoA biosynthetic process
long-chain fatty-acyl-CoA metabolic process
fatty-acyl-CoA biosynthetic process
fatty-acyl-CoA metabolic process
thioester biosynthetic process
acyl-CoA biosynthetic process
peroxisomal membrane
ribonucleoside bisphosphate biosynthetic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
fatty acid derivative biosynthetic process
thioester metabolic process
acyl-CoA metabolic process
long-chain fatty acid metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
mitochondrial outer membrane
fatty acid derivative metabolic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
purine ribonucleotide metabolic process
fatty acid metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process