ARHGAP11B

Entrez Summary: N/A
UniProt Summary: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis (PubMed:25721503). Does not possess GTPase activator activity (PubMed:25721503). {ECO:0000269|PubMed:25721503}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotinate 1000μM R03 exp140	-2.08
YM155 0.001μM R08 exp432	-2.05
Apcin 50 to 100μM on day4 R04 exp176	-1.97
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.87
Cidofovir 10μM R07 exp345	1.95
Demecolcine 0.03μM R05 exp228	2.03
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.39
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.41
UM131593 0.2μM R03 exp106	3.74

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebral cortex development
pallium development
telencephalon development
GTPase activator activity
regulation of small GTPase mediated signal transduction
forebrain development
positive regulation of GTPase activity
regulation of GTPase activity
brain development
positive regulation of hydrolase activity
head development
central nervous system development
regulation of hydrolase activity
positive regulation of catalytic activity
positive regulation of molecular function
regulation of intracellular signal transduction