BANP

Entrez Summary: This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
UniProt Summary: Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity). {ECO:0000250, ECO:0000269|PubMed:16166625}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 215/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	7/28
blood	9/28
bone	14/25
breast	13/33
central nervous system	19/56
cervix	1/4
colorectal	2/17
esophagus	5/13
fibroblast	1/1
gastric	2/15
kidney	4/21
liver	10/20
lung	26/75
lymphocyte	2/14
ovary	9/26
pancreas	7/24
peripheral nervous system	8/16
plasma cell	5/15
prostate	1/1
skin	3/24
soft tissue	1/7
thyroid	1/2
upper aerodigestive	2/22
urinary tract	7/29
uterus	1/5

Expression Distribution

p53 binding
negative regulation of protein catabolic process
protein localization to nucleus
regulation of signal transduction by p53 class mediator
nuclear body
negative regulation of catabolic process
regulation of protein catabolic process
chromatin organization
protein localization to organelle
regulation of catabolic process
chromosome organization
negative regulation of protein metabolic process
cell cycle
DNA binding
positive regulation of transcription, DNA-templated
cellular protein localization
cellular macromolecule localization
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
regulation of intracellular signal transduction
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process