BCDIN3D
Gene Information
- Official Symbol: BCDIN3D
- Official Name: BCDIN3 domain containing RNA methyltransferase
- Aliases and Previous Symbols: N/A
- Entrez ID: 144233
- UniProt: Q7Z5W3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast cancer. The encoded protein is thought to promote the cellular invasion of breast cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs. [provided by RefSeq, Apr 2017].
- UniProt Summary: O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre- miRNAs. {ECO:0000269|PubMed:23063121}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13919
- Expression level (log2 read counts): 3.33
BCDIN3D Expression in NALM6 Cells: 3.33
