BCO2

Entrez Summary: N/A
UniProt Summary: Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. {ECO:0000269|PubMed:21106934}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

beta,beta-carotene-9,10-cleaving oxygenase activity
beta-carotene 15,15-monooxygenase activity
carotenoid dioxygenase activity
xanthophyll metabolic process
terpene catabolic process
carotene catabolic process
carotene metabolic process
retinal isomerase activity
tetraterpenoid metabolic process
carotenoid metabolic process
terpene metabolic process
isoprenoid catabolic process
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
retinal metabolic process
retinoic acid metabolic process
cellular aldehyde metabolic process
regulation of mitochondrial membrane potential
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
isoprenoid metabolic process
regulation of reactive oxygen species metabolic process
cellular lipid catabolic process
hormone metabolic process
lipid catabolic process
mitochondrial matrix
regulation of membrane potential
monocarboxylic acid metabolic process
regulation of hormone levels
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
mitochondrion
small molecule metabolic process
organic substance catabolic process
cellular catabolic process