C1D

Entrez Summary: N/A
UniProt Summary: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). {ECO:0000250, ECO:0000269|PubMed:10362552, ECO:0000269|PubMed:11801738, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:9679063}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 15/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	0/5

Expression Distribution

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	-1.77
2-Deoxy-D-glucose 800μM R05 exp214	1.73
Bleomycin 5μM R08 exp459	1.77
Olaparib 4μM R08 exp512	1.8

nuclear exosome (RNase complex)
nuclear receptor binding
maturation of 5.8S rRNA
transcriptional repressor complex
rRNA processing
rRNA metabolic process
transcription corepressor activity
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
apoptotic process
programmed cell death
cell death
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
RNA metabolic process
negative regulation of gene expression
gene expression