CARD10
Gene Information
- Official Symbol: CARD10
- Official Name: caspase recruitment domain family member 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 29775
- UniProt: Q9BWT7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Activates NF-kappa-B via BCL10 and IKK.
Pfam Domains GO Terms
Pfam Domains
| CARD |
GO Terms
| CBM complex |
| negative regulation of cell migration involved in sprouting angiogenesis |
| CARD domain binding |
| activation of NF-kappaB-inducing kinase activity |
| receptor signaling complex adaptor activity |
| negative regulation of sprouting angiogenesis |
| negative regulation of blood vessel endothelial cell migration |
| regulation of cell migration involved in sprouting angiogenesis |
| negative regulation of endothelial cell migration |
| negative regulation of epithelial cell migration |
| regulation of sprouting angiogenesis |
| positive regulation of protein localization to nucleus |
| positive regulation of NIK/NF-kappaB signaling |
| NIK/NF-kappaB signaling |
| regulation of blood vessel endothelial cell migration |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| regulation of NIK/NF-kappaB signaling |
| negative regulation of vasculature development |
| regulation of protein localization to nucleus |
| regulation of endothelial cell migration |
| regulation of epithelial cell migration |
| negative regulation of cell migration |
| negative regulation of cell motility |
| regulation of angiogenesis |
| negative regulation of cellular component movement |
| regulation of vasculature development |
| negative regulation of locomotion |
| positive regulation of cellular protein localization |
| activation of protein kinase activity |
| positive regulation of protein kinase activity |
| regulation of cellular protein localization |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| regulation of protein kinase activity |
| regulation of cell migration |
| regulation of kinase activity |
| regulation of cell motility |
| regulation of cellular localization |
| negative regulation of developmental process |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MLN-4924 0.2μM R00 exp21 | -2.16 |
| Ethanol 0.01 R05 exp234 | -1.89 |
| BI-6727 0.001μM R01 exp42 | -1.74 |
| LLY-284 2.6μM R06 exp291 | 1.71 |
| THZ531 0.11 to 0.125μM on day4 R07 exp410 | 1.75 |
| ZLN024 50μM R08 exp538 | 1.78 |
| LB-100 2μM R05 exp210 | 1.82 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.406 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3071
- Expression level (log2 read counts): -1.39
Expression Distribution
CARD10 Expression in NALM6 Cells: -1.39
