CASP8AP2

Gene Information

Official Symbol: CASP8AP2
Official Name: caspase 8 associated protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 9994
UniProt: Q9UKL3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UMK57 1μM R01 exp59	-2.17
Palbociclib 1μM R07 exp382	-1.87
DABN racemic mixture R03 exp93	-1.86
Mitomycin-C 0.06μM R08 exp503	-1.76
Nutlin-3A 1.6μM R06 exp294	-1.76
MKC9989 10μM R03 exp133	1.7
Nifuroxazide 5μM R03 exp102	1.72
IU1-47 25μM R04 exp182	1.75
CHIR-124 0.04μM R06 exp272	1.79
S-DABN 8μM R03 exp112	1.79
Phenformin 20μM R03 exp143	1.85
Dynasore 10μM R04 exp180	2.23
UMK57 0.6μM R03 exp107	2.27

Essentiality in NALM6

Essentiality Rank: 1917
Expression level (log2 read counts): 7.17

Expression Distribution

Fas signaling pathway
peptidase activator activity involved in apoptotic process
SUMO polymer binding
death receptor binding
cysteine-type endopeptidase activator activity involved in apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
cellular response to mechanical stimulus
activation of cysteine-type endopeptidase activity involved in apoptotic process
extrinsic apoptotic signaling pathway
PML body
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
positive regulation of peptidase activity
response to mechanical stimulus
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
transcription corepressor activity
apoptotic signaling pathway
cellular response to abiotic stimulus
cellular response to environmental stimulus
cellular response to external stimulus
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
apoptotic process
programmed cell death
cell death
response to abiotic stimulus
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
mitochondrion
regulation of hydrolase activity
negative regulation of RNA metabolic process
cell cycle