CD28
Gene Information
- Official Symbol: CD28
- Official Name: CD28 molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 940
- UniProt: P10747
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| protein complex involved in cell adhesion |
| regulatory T cell differentiation |
| positive regulation of isotype switching to IgG isotypes |
| negative thymic T cell selection |
| positive regulation of inflammatory response to antigenic stimulus |
| negative T cell selection |
| regulation of isotype switching to IgG isotypes |
| positive regulation of interleukin-2 biosynthetic process |
| cytokine biosynthetic process |
| cytokine metabolic process |
| thymic T cell selection |
| regulation of interleukin-2 biosynthetic process |
| positive regulation of alpha-beta T cell proliferation |
| positive regulation of interleukin-4 production |
| regulation of inflammatory response to antigenic stimulus |
| positive regulation of isotype switching |
| regulation of interleukin-4 production |
| regulation of regulatory T cell differentiation |
| regulation of defense response to virus by virus |
| positive regulation of interleukin-2 production |
| regulation of alpha-beta T cell proliferation |
| regulation of isotype switching |
| positive regulation of viral genome replication |
| coreceptor activity |
| immunological synapse |
| positive regulation of interleukin-10 production |
| positive regulation of immunoglobulin mediated immune response |
| positive regulation of B cell mediated immunity |
| T cell selection |
| positive regulation of DNA recombination |
| positive regulation of immunoglobulin production |
| T cell differentiation in thymus |
| regulation of immunoglobulin mediated immune response |
| regulation of B cell mediated immunity |
| regulation of interleukin-10 production |
| positive regulation of mitotic nuclear division |
| SH3/SH2 adaptor activity |
| T cell costimulation |
| regulation of interleukin-2 production |
| lymphocyte costimulation |
| positive regulation of alpha-beta T cell activation |
| positive regulation of viral life cycle |
| regulation of immunoglobulin production |
| positive regulation of nuclear division |
| positive regulation of cytokine biosynthetic process |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| regulation of alpha-beta T cell activation |
| regulation of viral genome replication |
| positive regulation of T cell proliferation |
| positive regulation of production of molecular mediator of immune response |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| protease binding |
| regulation of DNA recombination |
| regulation of cytokine biosynthetic process |
| positive regulation of adaptive immune response |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of viral process |
| regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of translation |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte mediated immunity |
| T cell differentiation |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| positive regulation of inflammatory response |
| regulation of production of molecular mediator of immune response |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of viral life cycle |
| cytokine production |
| regulation of lymphocyte mediated immunity |
| positive regulation of cellular amide metabolic process |
| positive regulation of mitotic cell cycle |
| regulation of T cell proliferation |
| regulation of adaptive immune response |
| positive regulation of protein kinase B signaling |
| positive regulation of B cell activation |
| regulation of mitotic nuclear division |
| regulation of lymphocyte differentiation |
| T cell receptor signaling pathway |
| regulation of nuclear division |
| positive regulation of DNA metabolic process |
| positive regulation of T cell activation |
| regulation of viral process |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of protein kinase B signaling |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of leukocyte proliferation |
| T cell activation |
| lymphocyte differentiation |
| positive regulation of cell-cell adhesion |
| regulation of leukocyte differentiation |
| apoptotic signaling pathway |
| positive regulation of cell cycle process |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| leukocyte differentiation |
| regulation of inflammatory response |
| humoral immune response |
| regulation of translation |
| regulation of DNA metabolic process |
| positive regulation of lymphocyte activation |
| positive regulation of cell cycle |
| lymphocyte activation |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| regulation of cellular amide metabolic process |
| positive regulation of cell activation |
| immune response-activating cell surface receptor signaling pathway |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| protein kinase binding |
| regulation of immune effector process |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| posttranscriptional regulation of gene expression |
| hemopoiesis |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| cell surface |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| activation of immune response |
| regulation of cell activation |
| immune system development |
| regulation of cell adhesion |
| regulation of cytokine production |
| viral process |
| regulation of cell cycle process |
| regulation of defense response |
| regulation of multi-organism process |
| symbiotic process |
| interspecies interaction between organisms |
| positive regulation of immune response |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| apoptotic process |
| leukocyte activation |
| negative regulation of cell death |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| identical protein binding |
| cell activation |
| cell death |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| regulation of organelle organization |
| positive regulation of developmental process |
| integral component of plasma membrane |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15550
- Expression level (log2 read counts): 1.03
Expression Distribution
CD28 Expression in NALM6 Cells: 1.03
