CDC37L1

Entrez Summary: N/A
UniProt Summary: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Diepoxybutane 3μM R07 exp354	-2.65
Bortezomib 0.005μM R00 exp6	-2.26
Oligomycin-A 2μM R00 exp25	-2.04
TRAIL 5ng/ml R00 exp35	-2.02
Parthenolide 2.5μM R05 exp238	-1.92
Cidofovir 10μM R07 exp345	-1.85
Ibrutinib 1μM R07 exp372	-1.7
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.57

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

platelet dense granule lumen
heat shock protein binding
chaperone binding
platelet degranulation
unfolded protein binding
protein stabilization
protein folding
regulation of protein stability
regulated exocytosis
exocytosis
secretion by cell
export from cell
secretion
extracellular region
vesicle-mediated transport