CDK18

Entrez Summary: N/A
UniProt Summary: May play a role in signal transduction cascades in terminally differentiated cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I2 1μM R06 exp286	-1.94
Selumetinib 20μM R02 exp81	-1.89
UM131593 0.1μM R01 exp58	-1.84
BI-6727 0.001μM R01 exp42	-1.74
Wortmannin 5μM R00 exp38	-1.73
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.86

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

cyclin-dependent protein serine/threonine kinase activity
protein serine/threonine kinase activity
cellular component
protein phosphorylation
regulation of cell cycle
phosphorylation
ATP binding