CLEC16A

Gene Information

Official Symbol: CLEC16A
Official Name: C-type lectin domain containing 16A
Aliases and Previous Symbols: N/A
Entrez ID: 23274
UniProt: Q2KHT3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
UniProt Summary: Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. {ECO:0000269|PubMed:24949970}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-2.36
UM0011500 5μM R05 exp245	-1.99
42°C R08 exp539	-1.88
Bafilomycin-A1 0.009μM R08 exp454	-1.8
CFI-400945 25μM R08 exp469	-1.79
Vemurafenib 6.6μM R02 exp89	-1.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6797
Expression level (log2 read counts): 5.68

Expression Distribution

negative regulation of macroautophagy by TORC1 signaling
negative regulation of autophagosome maturation
negative regulation of mitophagy
positive regulation of autophagosome maturation
TORC1 signaling
negative regulation of autophagy of mitochondrion
regulation of autophagosome maturation
endolysosome membrane
positive regulation of TORC1 signaling
regulation of mitophagy
TOR signaling
negative regulation of macroautophagy
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein complex disassembly
positive regulation of TOR signaling
regulation of TORC1 signaling
regulation of autophagy of mitochondrion
negative regulation of ubiquitin-dependent protein catabolic process
endosome to lysosome transport
negative regulation of mitochondrion organization
negative regulation of proteasomal protein catabolic process
positive regulation of macroautophagy
negative regulation of protein complex disassembly
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of autophagy
negative regulation of cellular protein catabolic process
regulation of TOR signaling
lysosomal transport
regulation of protein complex disassembly
positive regulation of autophagy
regulation of proteasomal ubiquitin-dependent protein catabolic process
late endosome
negative regulation of protein catabolic process
vacuolar transport
vesicle
Rab GTPase binding
cellular response to starvation
regulation of ubiquitin-dependent protein catabolic process
regulation of macroautophagy
regulation of mitochondrion organization