CLIC4

Entrez Summary: N/A
UniProt Summary: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.82
Chloramphenicol 20μM R00 exp13	1.77
TRAIL 5ng/ml R00 exp35	1.81
Quercetin 20μM R08 exp517	1.89
Pimelic-diphenylamide-106 0.5μM R00 exp27	2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

voltage-gated ion channel activity
chloride channel complex
establishment or maintenance of apical/basal cell polarity
establishment or maintenance of bipolar cell polarity
chloride channel activity
microvillus
apical part of cell
cellular response to calcium ion
intracellular
chloride transmembrane transport
chloride transport
inorganic anion transmembrane transport
nuclear matrix
cytoplasmic vesicle membrane
response to calcium ion
microtubule cytoskeleton
midbody
inorganic anion transport
cell-cell junction
cellular response to metal ion
establishment or maintenance of cell polarity
actin cytoskeleton
cellular response to inorganic substance
negative regulation of cell migration
negative regulation of cell motility
keratinocyte differentiation
anion transmembrane transport
negative regulation of cellular component movement
epidermal cell differentiation
angiogenesis
negative regulation of locomotion
response to metal ion
skin development
blood vessel morphogenesis
epidermis development
regulation of ion transmembrane transport
blood vessel development
centrosome
vasculature development
cardiovascular system development