CLPB
Gene Information
- Official Symbol: CLPB
- Official Name: caseinolytic mitochondrial matrix peptidase chaperone subunit B
- Aliases and Previous Symbols: N/A
- Entrez ID: 81570
- UniProt: Q9H078
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
- UniProt Summary: May function as a regulatory ATPase and be related to secretion/protein trafficking process.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2708
- Expression level (log2 read counts): 5.58
CLPB Expression in NALM6 Cells: 5.58
