CMAS

Entrez Summary: N/A
UniProt Summary: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docosahexaenoic-acid 50μM R07 exp356	-2.26
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.99
CB-839 10μM R05 exp224	-1.86
Q15 1 to 2μM on day4 R04 exp164	-1.81
GSK626616 14μM R08 exp485	1.71
Senexin-A 25μM R07 exp400	1.74
Lead acetate 2000μM R08 exp498 no dilution day6	1.79
Tunicamycin 0.04μM R07 exp418	1.8
Golgicide-A 4μM R03 exp122	1.84
RO-3307 4.7μM R02 exp80	1.94
ML-792 0.2μM R08 exp505	2.07
Rapamycin 0.001μM R08 exp429	2.1
Torin1 0.08μM R02 exp82	2.11
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.13
MK-1775 0.32μM R02 exp75	2.24
Nicotine 3000μM R08 exp510	2.26
Rapamycin 10μM R00 exp30	2.29
EPZ-5676 30μM R05 exp233	2.57
Staurosporine 0.02μM R08 exp524	2.59
Ethanol 0.01 R05 exp234	2.69
Thapsigargin 0.005μM R07 exp407	2.71
UM0011500 10μM R05 exp246	2.72
Temozolomide 200μM R04 exp189	2.79
BI-D1870 3.15μM R02 exp66	2.82
MK2206 4μM R08 exp504	2.95
Hippuristanol 0.12μM R08 exp488	3.22
UM0129480 7μM R02 exp85	3.33
WYE-354 6μM R02 exp90	3.79
Erlotinib 10μM R05 exp216	4.25

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NTP transf 3
CTP transf 3

N-acylneuraminate cytidylyltransferase activity
N-acetylneuraminate metabolic process
amino sugar metabolic process
antibiotic metabolic process
drug metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
small molecule metabolic process
membrane