CPVL

Entrez Summary: N/A
UniProt Summary: May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LJH685 50μM R08 exp433	-1.77
R-DABN 8μM R03 exp111	1.78
Dynasore 7μM R08 exp436	1.84
Nocodazole 0.2μM R02 exp64	1.86
All-trans-Retinoic-Acid 40μM R07 exp334	1.89
Tozasertib 0.1μM R07 exp414	2.19
Methotrexate 0.01μM R08 exp501	2.23
Rotenone 2μM R00 exp33	2.75
Nocodazole 0.2μM R00 exp24	3.39
Nocodazole 0.1μM R03 exp94	4.04

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

serine-type carboxypeptidase activity
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
cellular macromolecule catabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
organic substance catabolic process
cellular catabolic process