CRTC3

Gene Information

Official Symbol: CRTC3
Official Name: CREB regulated transcription coactivator 3
Aliases and Previous Symbols: N/A
Entrez ID: 64784
UniProt: Q6UUV7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012].
UniProt Summary: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.27
IU1-47 25μM R04 exp182	-1.97
SGC2043 10μM R03 exp152	-1.78
Ibrutinib 10μM R08 exp442	-1.77
ETC-159 50μM R08 exp480	-1.7

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7082
Expression level (log2 read counts): 4.37

Expression Distribution

TORC N
TORC M
TORC C

cAMP response element binding protein binding
positive regulation of CREB transcription factor activity
negative regulation of cAMP-mediated signaling
negative regulation of lipid catabolic process
energy homeostasis
regulation of cAMP-mediated signaling
macrophage activation
regulation of lipid catabolic process
negative regulation of lipid metabolic process
protein homotetramerization
protein tetramerization
positive regulation of DNA-binding transcription factor activity
negative regulation of catabolic process
multicellular organismal homeostasis
protein homooligomerization
regulation of lipid metabolic process
regulation of DNA-binding transcription factor activity
negative regulation of intracellular signal transduction
protein complex oligomerization
myeloid leukocyte activation
viral process
symbiotic process
interspecies interaction between organisms
leukocyte activation
regulation of catabolic process
cell activation
positive regulation of transcription by RNA polymerase II
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
positive regulation of transcription, DNA-templated
protein-containing complex assembly
negative regulation of response to stimulus
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
homeostatic process
positive regulation of RNA metabolic process
positive regulation of molecular function
regulation of intracellular signal transduction
protein-containing complex subunit organization