CSRP2BP

Entrez Summary: N/A
UniProt Summary: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. {ECO:0000269|PubMed:19103755}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

LIM domain binding
Ada2/Gcn5/Ada3 transcription activator complex
histone H3 acetylation
histone acetyltransferase activity
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
protein acetylation
protein acylation
mitotic cell cycle phase transition
cell cycle phase transition
peptidyl-lysine modification
histone modification
covalent chromatin modification
mitotic cell cycle process
mitotic cell cycle
chromatin organization
peptidyl-amino acid modification
cell cycle process
chromosome organization
cell cycle