CUX1

Gene Information

Official Symbol: CUX1
Official Name: cut like homeobox 1
Aliases and Previous Symbols: N/A
Entrez ID: 1523
UniProt: Q13948"|"P39880|Q13948"
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phenformin 20μM R03 exp143	-1.81
Cerivastatin 0.15μM R05 exp226	-1.77
Chloramphenicol 2μM R00 exp12	-1.75
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.95
FTY720 3μM R08 exp483	1.96
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.08
I-BRD9 4μM R07 exp365	2.39
LY2090314 0.003μM R08 exp500 no dilution day6	2.67
LY2090314 0.003μM R08 exp499	2.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12276
Expression level (log2 read counts): 7.12

Expression Distribution

CUT
Homeobox
CASP C

retrograde transport, vesicle recycling within Golgi
intra-Golgi vesicle-mediated transport
positive regulation of dendrite morphogenesis
positive regulation of dendrite development
protein binding, bridging
regulation of dendrite morphogenesis
regulation of dendrite development
positive regulation of cell morphogenesis involved in differentiation
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of neuron differentiation
Golgi vesicle transport
positive regulation of cell projection organization
sequence-specific DNA binding
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
Golgi membrane
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
negative regulation of transcription by RNA polymerase II
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
Golgi apparatus
regulation of anatomical structure morphogenesis
negative regulation of transcription, DNA-templated
positive regulation of cellular component organization
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
positive regulation of developmental process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process