CYTH1

Entrez Summary: N/A
UniProt Summary: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity). {ECO:0000250|UniProtKB:Q9QX11, ECO:0000269|PubMed:10652308, ECO:0000269|PubMed:9653114}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PH
Sec7

ARF guanyl-nucleotide exchange factor activity
regulation of ARF protein signal transduction
establishment of epithelial cell polarity
extrinsic component of cytoplasmic side of plasma membrane
adherens junction
establishment of cell polarity
bicellular tight junction
lipid binding
establishment or maintenance of cell polarity
regulation of Ras protein signal transduction
regulation of small GTPase mediated signal transduction
Golgi membrane
regulation of cell adhesion
regulation of intracellular signal transduction
vesicle-mediated transport