DCTD

Gene Information

Official Symbol: DCTD
Official Name: dCMP deaminase
Aliases and Previous Symbols: N/A
Entrez ID: 1635
UniProt: P32321
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Supplies the nucleotide substrate for thymidylate synthetase.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Resveratrol 16μM R03 exp147	-1.92
ABT-702 5μM R06 exp261	-1.7
BS-181 20μM R08 exp461	1.71
Taxol 0.004μM R03 exp103	1.79
Aphidicolin 0.4μM R08 exp440	2.72
FBS-Wisent 0.1 R07 exp426	3

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10240
Expression level (log2 read counts): 6.06

Expression Distribution

dCMP deaminase activity
dUMP biosynthetic process
dTMP metabolic process
dTMP biosynthetic process
dUMP metabolic process
pyrimidine deoxyribonucleoside monophosphate biosynthetic process
pyrimidine deoxyribonucleoside monophosphate metabolic process
pyrimidine deoxyribonucleotide biosynthetic process
deoxyribonucleoside monophosphate biosynthetic process
2-deoxyribonucleotide biosynthetic process
deoxyribose phosphate biosynthetic process
deoxyribonucleoside monophosphate metabolic process
deoxyribonucleotide biosynthetic process
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine nucleoside monophosphate metabolic process
pyrimidine deoxyribonucleotide metabolic process
nucleobase-containing small molecule interconversion
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
nucleoside monophosphate biosynthetic process
pyrimidine nucleotide biosynthetic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
nucleoside monophosphate metabolic process
pyrimidine-containing compound metabolic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
zinc ion binding
organophosphate metabolic process
carbohydrate derivative metabolic process
identical protein binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process