DEFB114

Gene Information

Official Symbol: DEFB114
Official Name: defensin beta 114
Aliases and Previous Symbols: N/A
Entrez ID: 245928
UniProt: Q30KQ6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS- induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. {ECO:0000269|PubMed:23482568}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol A 100μM R06 exp269	-1.95
B02 10μM R08 exp453	-1.76
HMS-I2 10μM R06 exp288	1.81
ABT-702 0.1μM R06 exp260	1.88
Bortezomib 0.05μM R00 exp7	1.99
Pimelic-diphenylamide-106 0.5μM R00 exp27	3.62

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14224
Expression level (log2 read counts): -7.68

Expression Distribution

antifungal innate immune response
negative regulation of tumor necrosis factor secretion
negative regulation of lipopolysaccharide-mediated signaling pathway
regulation of lipopolysaccharide-mediated signaling pathway
regulation of tumor necrosis factor secretion
lipopolysaccharide binding
defense response to fungus
response to fungus
negative regulation of tumor necrosis factor production
negative regulation of tumor necrosis factor superfamily cytokine production
negative regulation of cytokine secretion
negative regulation of MAP kinase activity
defense response to Gram-negative bacterium
negative regulation of response to biotic stimulus
defense response to Gram-positive bacterium
negative regulation of protein secretion
negative regulation of protein serine/threonine kinase activity
negative regulation of peptide secretion
positive regulation of inflammatory response
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
negative regulation of MAPK cascade
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of cytokine secretion
negative regulation of multi-organism process
negative regulation of protein kinase activity
negative regulation of secretion
negative regulation of kinase activity
negative regulation of cytokine production
negative regulation of transferase activity
defense response to bacterium
regulation of inflammatory response
regulation of MAP kinase activity
negative regulation of response to external stimulus
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of protein secretion
positive regulation of defense response