DGKB

Entrez Summary: Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

diacylglycerol kinase activity
NAD+ kinase activity
diacylglycerol metabolic process
protein kinase C-activating G protein-coupled receptor signaling pathway
lipid phosphorylation
Schaffer collateral - CA1 synapse
regulation of postsynapse organization
acylglycerol metabolic process
neutral lipid metabolic process
platelet activation
lipid modification
regulation of synapse organization
regulation of synapse structure or activity
blood coagulation
coagulation
hemostasis
glutamatergic synapse
glycerolipid metabolic process
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
wound healing
regulation of body fluid levels
response to wounding
response to bacterium
calcium ion binding
cellular lipid metabolic process
cell activation
lipid metabolic process
phosphorylation
response to other organism
response to external biotic stimulus
G protein-coupled receptor signaling pathway
response to biotic stimulus
ATP binding
intracellular signal transduction