DKK1
Gene Information
- Official Symbol: DKK1
- Official Name: dickkopf WNT signaling pathway inhibitor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 22943
- UniProt: O94907
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti- apoptotic activity (By similarity). {ECO:0000250|UniProtKB:O54908, ECO:0000269|PubMed:22000856, ECO:0000303|PubMed:17143291}.
Pfam Domains GO Terms
Pfam Domains
| Dickkopf N |
GO Terms
| regulation of Wnt signaling pathway, calcium modulating pathway |
| regulation of Wnt-Frizzled-LRP5/6 complex assembly |
| negative regulation of Wnt-Frizzled-LRP5/6 complex assembly |
| negative regulation of presynapse assembly |
| positive regulation of Wnt signaling pathway, calcium modulating pathway |
| negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment |
| negative regulation of canonical Wnt signaling pathway involved in heart development |
| positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway |
| regulation of canonical Wnt signaling pathway involved in heart development |
| regulation of endodermal cell fate specification |
| regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment |
| regulation of heart induction by regulation of canonical Wnt signaling pathway |
| positive regulation of midbrain dopaminergic neuron differentiation |
| positive regulation of dopaminergic neuron differentiation |
| negative regulation of mesodermal cell fate specification |
| regulation of endodermal cell differentiation |
| negative regulation of mesodermal cell differentiation |
| negative regulation of mesoderm formation |
| Wnt signaling pathway involved in somitogenesis |
| regulation of midbrain dopaminergic neuron differentiation |
| positive regulation of heart induction |
| negative regulation of Wnt signaling pathway involved in heart development |
| motor learning |
| regulation of Wnt signaling pathway involved in heart development |
| regulation of heart induction |
| negative regulation of cell fate specification |
| positive regulation of tau-protein kinase activity |
| regulation of mesodermal cell differentiation |
| negative regulation of synapse assembly |
| negative regulation of gastrulation |
| regulation of mesodermal cell fate specification |
| regulation of mesoderm formation |
| negative regulation of mesoderm development |
| positive regulation of Wnt signaling pathway, planar cell polarity pathway |
| modulation of age-related behavioral decline |
| regulation of dopaminergic neuron differentiation |
| regulation of tau-protein kinase activity |
| negative regulation of pathway-restricted SMAD protein phosphorylation |
| synapse pruning |
| negative regulation of skeletal muscle tissue development |
| regulation of cell fate specification |
| negative regulation of cell fate commitment |
| positive regulation of non-canonical Wnt signaling pathway |
| co-receptor binding |
| regulation of Wnt signaling pathway, planar cell polarity pathway |
| negative regulation of cardiac muscle cell differentiation |
| regulation of mesoderm development |
| low-density lipoprotein particle receptor binding |
| negative regulation of cardiocyte differentiation |
| regulation of non-canonical Wnt signaling pathway |
| negative regulation of synapse organization |
| negative regulation of embryonic development |
| negative regulation of peptidyl-serine phosphorylation |
| receptor antagonist activity |
| regulation of cell fate commitment |
| regulation of presynapse assembly |
| regulation of presynapse organization |
| face morphogenesis |
| negative regulation of cardiac muscle tissue development |
| regulation of cardiac muscle cell differentiation |
| regulation of animal organ formation |
| regulation of gastrulation |
| head morphogenesis |
| negative regulation of striated muscle cell differentiation |
| regulation of heart morphogenesis |
| body morphogenesis |
| endoderm formation |
| negative regulation of striated muscle tissue development |
| face development |
| regulation of skeletal muscle tissue development |
| negative regulation of muscle organ development |
| negative regulation of BMP signaling pathway |
| regulation of cardiocyte differentiation |
| negative regulation of muscle tissue development |
| regulation of receptor internalization |
| negative regulation of muscle cell differentiation |
| negative regulation of signaling receptor activity |
| regulation of pathway-restricted SMAD protein phosphorylation |
| somitogenesis |
| mesoderm formation |
| mesoderm morphogenesis |
| regulation of synaptic transmission, glutamatergic |
| hair follicle development |
| positive regulation of JUN kinase activity |
| endoderm development |
| skin epidermis development |
| negative regulation of ossification |
| hair cycle process |
| molting cycle process |
| regulation of cardiac muscle tissue development |
| positive regulation of animal organ morphogenesis |
| somite development |
| regulation of JUN kinase activity |
| regulation of BMP signaling pathway |
| hair cycle |
| positive regulation of neuron death |
| molting cycle |
| segmentation |
| regulation of receptor-mediated endocytosis |
| regulation of striated muscle cell differentiation |
| negative regulation of protein binding |
| regulation of synapse assembly |
| response to retinoic acid |
| regulation of establishment of planar polarity |
| formation of primary germ layer |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| mesoderm development |
| embryonic appendage morphogenesis |
| embryonic limb morphogenesis |
| regulation of embryonic development |
| negative regulation of protein complex assembly |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| regulation of peptidyl-serine phosphorylation |
| positive regulation of JNK cascade |
| learning |
| negative regulation of cellular response to growth factor stimulus |
| limb morphogenesis |
| appendage morphogenesis |
| early endosome membrane |
| regulation of muscle cell differentiation |
| negative regulation of neuron projection development |
| gastrulation |
| growth factor activity |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| negative regulation of binding |
| regulation of signaling receptor activity |
| negative regulation of canonical Wnt signaling pathway |
| positive regulation of Wnt signaling pathway |
| limb development |
| regulation of morphogenesis of an epithelium |
| appendage development |
| negative regulation of cell projection organization |
| regulation of JNK cascade |
| regulation of ossification |
| regulation of endocytosis |
| negative regulation of Wnt signaling pathway |
| anterior/posterior pattern specification |
| regulation of synapse organization |
| regulation of protein binding |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| regulation of stress-activated MAPK cascade |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of stress-activated protein kinase signaling cascade |
| regulation of animal organ morphogenesis |
| learning or memory |
| positive regulation of MAP kinase activity |
| synapse organization |
| regulation of cellular response to growth factor stimulus |
| aging |
| regulation of canonical Wnt signaling pathway |
| negative regulation of neurogenesis |
| cognition |
| regulation of neuron death |
| negative regulation of nervous system development |
| regionalization |
| negative regulation of cell development |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| response to acid chemical |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| positive regulation of neuron differentiation |
| regulation of binding |
| skin development |
| forebrain development |
| cellular component disassembly |
| negative regulation of protein phosphorylation |
| epidermis development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| pattern specification process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| negative regulation of phosphorylation |
| regulation of protein complex assembly |
| positive regulation of neurogenesis |
| regulation of neuron projection development |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| embryonic morphogenesis |
| behavior |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| regulation of cellular response to stress |
| brain development |
| regulation of MAPK cascade |
| head development |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| cellular component morphogenesis |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| embryo development |
| central nervous system development |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| negative regulation of protein metabolic process |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| extracellular region |
| system process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRIM1 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12781
- Expression level (log2 read counts): -3.8
Expression Distribution
DKK1 Expression in NALM6 Cells: -3.8
