DNAJC2

Entrez Summary: N/A
UniProt Summary: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R02 exp89	-1.71
BI-D1870 3.15μM R02 exp66	1.73
Oligomycin-A 2μM R00 exp25	1.76
Lead acetate 2000μM R08 exp498 no dilution day6	1.77
Arsenate 40μM R06 exp264	1.96
Hippuristanol 0.12μM R08 exp488	2.06
Wortmannin 5μM R00 exp38	2.06
KU-0063794 3.8μM R02 exp71	2.12
INK128 0.2μM R02 exp70	2.2
Rapamycin 1μM R00 exp29	2.24
CB-5083 0.4μM R08 exp468	2.55
Rapamycin 10μM R00 exp30	2.76
MK2206 4μM R08 exp504	3.5

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Myb DNA-binding
DnaJ

de novo cotranslational protein folding
ubiquitin modification-dependent histone binding
negative regulation of DNA biosynthetic process
de novo protein folding
Hsp70 protein binding
regulation of cellular response to heat
regulation of DNA biosynthetic process
negative regulation of DNA metabolic process
histone binding
DNA replication
protein folding
nuclear membrane
regulation of DNA metabolic process
chromatin binding
chromatin organization
regulation of cellular response to stress
chromosome organization
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
regulation of response to stress
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process