DRG1
Gene Information
- Official Symbol: DRG1
- Official Name: developmentally regulated GTP binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4733
- UniProt: Q9Y295
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.
Pfam Domains GO Terms
Pfam Domains
| TGS |
| FeoB N |
| MMR HSR1 |
GO Terms
| potassium ion binding |
| regulation of mitotic spindle assembly |
| regulation of spindle assembly |
| positive regulation of microtubule polymerization |
| positive regulation of microtubule polymerization or depolymerization |
| regulation of mitotic spindle organization |
| regulation of spindle organization |
| polysome |
| regulation of microtubule polymerization |
| cytoplasmic translation |
| regulation of microtubule polymerization or depolymerization |
| positive regulation of protein polymerization |
| regulation of mitotic nuclear division |
| regulation of microtubule cytoskeleton organization |
| regulation of nuclear division |
| positive regulation of supramolecular fiber organization |
| regulation of organelle assembly |
| positive regulation of cytoskeleton organization |
| regulation of microtubule-based process |
| regulation of protein polymerization |
| microtubule binding |
| positive regulation of protein complex assembly |
| nuclear body |
| GTPase activity |
| transcription factor binding |
| regulation of supramolecular fiber organization |
| translation |
| GTP binding |
| peptide biosynthetic process |
| regulation of protein complex assembly |
| positive regulation of cellular component biogenesis |
| amide biosynthetic process |
| peptide metabolic process |
| regulation of cytoskeleton organization |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| regulation of cell cycle process |
| cellular amide metabolic process |
| regulation of cellular component biogenesis |
| identical protein binding |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ZC3H15 | 0.487 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 8/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7823
- Expression level (log2 read counts): 5.89
Expression Distribution
DRG1 Expression in NALM6 Cells: 5.89
