EFNB3

Entrez Summary: N/A
UniProt Summary: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
axon choice point recognition
trans-synaptic signaling by trans-synaptic complex
trans-synaptic signaling, modulating synaptic transmission
transmembrane-ephrin receptor activity
ephrin receptor binding
adult walking behavior
walking behavior
hippocampal mossy fiber to CA3 synapse
neuron recognition
integral component of postsynaptic density membrane
T cell costimulation
lymphocyte costimulation
integral component of presynaptic membrane
negative regulation of axonogenesis
virus receptor activity
adult locomotory behavior
ephrin receptor signaling pathway
viral entry into host cell
negative regulation of cell morphogenesis involved in differentiation
entry into host cell
entry into host
adult behavior
negative regulation of neuron projection development
interaction with host
negative regulation of cell projection organization
regulation of axonogenesis
locomotory behavior
viral life cycle
positive regulation of T cell activation
positive regulation of leukocyte cell-cell adhesion
negative regulation of neuron differentiation
cell recognition
positive regulation of cell-cell adhesion
axon guidance
neuron projection guidance
negative regulation of neurogenesis
regulation of leukocyte cell-cell adhesion
regulation of cell morphogenesis involved in differentiation
negative regulation of nervous system development