EIF2AK1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 2μM R05 exp210	1.73
Zebularine 20μM R07 exp423	1.74
Dynasore 7μM R08 exp436	1.76
KU-0063794 3.8μM R02 exp71	1.77
NN-Dimethylsphingosine 2.5μM R08 exp508	1.81
UM0129480 7μM R02 exp85	1.81
BI-6727 0.0125μM R03 exp97	1.84
Tubastatin-A 2.5μM R07 exp417	1.86
35°C R06 exp302	1.89
Torin1 0.08μM R02 exp82	1.93
Cannabidiol 13μM R08 exp465	1.99
All-trans-Retinoic-Acid 40μM R07 exp334	2.03
Nocodazole 0.2μM R02 exp64	2.07
Nocodazole 0.1μM R03 exp94	2.19
MK-1775 0.32μM R02 exp75	2.22
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.57
Calcium Ionophore 0.4μM R07 exp342	2.65
Oligomycin-A 2μM R00 exp25	2.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
KIAA0141	0.47
OMA1	0.419

Pkinase
Pkinase Tyr

negative regulation of translational initiation by iron
negative regulation of hemoglobin biosynthetic process
regulation of eIF2 alpha phosphorylation by heme
regulation of translational initiation by iron
response to iron ion starvation
regulation of hemoglobin biosynthetic process
regulation of translational initiation by eIF2 alpha phosphorylation
eukaryotic translation initiation factor 2alpha kinase activity
regulation of translational initiation in response to stress
protoporphyrinogen IX metabolic process
regulation of translation in response to stress
negative regulation of translational initiation
macrophage differentiation
porphyrin-containing compound metabolic process
tetrapyrrole metabolic process
acute inflammatory response
regulation of translational initiation
iron ion homeostasis
myeloid leukocyte differentiation
negative regulation of translation
transition metal ion homeostasis
heme binding
negative regulation of cellular amide metabolic process
protein autophosphorylation
response to starvation
myeloid cell differentiation
protein kinase activity
phagocytosis
leukocyte differentiation
regulation of translation
regulation of cellular amide metabolic process
cofactor metabolic process
response to nutrient levels
inflammatory response
posttranscriptional regulation of gene expression
response to extracellular stimulus
hemopoiesis
hematopoietic or lymphoid organ development
metal ion homeostasis
immune system development