ELOVL1

Gene Information

Official Symbol: ELOVL1
Official Name: ELOVL fatty acid elongase 1
Aliases and Previous Symbols: N/A
Entrez ID: 64834
UniProt: Q9BW60
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000269|PubMed:20166112, ECO:0000269|PubMed:20937905}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 1 to 2μM on day4 R04 exp164	-3.14
NN-Dimethylsphingosine 2.5μM R08 exp508	-3.11
MKC9989 10μM R03 exp133	-2.08
FTY720 3μM R08 exp483	-1.97
Q15 2.7μM R02 exp79	-1.88
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.81
Lead acetate 2000μM R08 exp498 no dilution day6	-1.79
Pyronaridine 1μM R06 exp295	-1.73
Tubacin 1.6μM R07 exp416	1.77
Genistein 15μM R07 exp360	1.84
Tunicamycin 0.04μM R07 exp418	2.34
Arsenate 40μM R06 exp264	2.48
TRAIL 5ng/ml R00 exp35	3.2

Global Fraction of Cell Lines Where Essential: 7/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11164
Expression level (log2 read counts): 5.37

Expression Distribution

fatty acid elongation, monounsaturated fatty acid
fatty acid elongation, saturated fatty acid
3-oxo-arachidoyl-CoA synthase activity
very-long-chain 3-ketoacyl-CoA synthase activity
fatty acid elongation, polyunsaturated fatty acid
3-oxo-lignoceronyl-CoA synthase activity
fatty acid elongation, unsaturated fatty acid
3-oxo-cerotoyl-CoA synthase activity
fatty acid elongase activity
very long-chain fatty acid biosynthetic process
fatty acid elongation
alpha-linolenic acid metabolic process
linoleic acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
establishment of skin barrier
long-chain fatty-acyl-CoA metabolic process
regulation of water loss via skin
very long-chain fatty acid metabolic process
fatty-acyl-CoA biosynthetic process
fatty-acyl-CoA metabolic process
unsaturated fatty acid biosynthetic process
thioester biosynthetic process
acyl-CoA biosynthetic process
ceramide biosynthetic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
ribonucleoside bisphosphate biosynthetic process
multicellular organismal water homeostasis
water homeostasis
ceramide metabolic process
sphingolipid biosynthetic process
fatty acid derivative biosynthetic process
acyl-CoA metabolic process
thioester metabolic process
integral component of endoplasmic reticulum membrane
unsaturated fatty acid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
membrane lipid biosynthetic process
ribonucleoside bisphosphate metabolic process