ERLIN2

Gene Information

Official Symbol: ERLIN2
Official Name: ER lipid raft associated 2
Aliases and Previous Symbols: N/A
Entrez ID: 11160
UniProt: O94905
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
UniProt Summary: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). {ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031, ECO:0000269|PubMed:21343306, ECO:0000269|PubMed:24217618}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4546
Expression level (log2 read counts): 5.89

Expression Distribution

Screen	Score
Ribavirin 10μM R01 exp52	-3.05
Thapsigargin 0.005μM R07 exp407	-2.75
Hypoxia 5%O2 R04 exp191	-1.74
VE-822 0.04μM R06 exp300	2.37

negative regulation of cholesterol metabolic process
negative regulation of sterol biosynthetic process
negative regulation of cholesterol biosynthetic process
SREBP signaling pathway
cellular response to sterol depletion
response to sterol depletion
negative regulation of alcohol biosynthetic process
negative regulation of fatty acid biosynthetic process
negative regulation of steroid biosynthetic process
negative regulation of steroid metabolic process
negative regulation of fatty acid metabolic process
ER-nucleus signaling pathway
regulation of sterol biosynthetic process
regulation of cholesterol biosynthetic process
regulation of fatty acid biosynthetic process
negative regulation of lipid biosynthetic process
cholesterol binding
regulation of cholesterol metabolic process
ubiquitin-dependent ERAD pathway
regulation of alcohol biosynthetic process
negative regulation of lipid metabolic process
regulation of fatty acid metabolic process
regulation of steroid biosynthetic process
ERAD pathway
negative regulation of small molecule metabolic process
regulation of steroid metabolic process
cholesterol metabolic process
secondary alcohol metabolic process
sterol metabolic process
regulation of cellular ketone metabolic process
regulation of lipid biosynthetic process
membrane raft
response to endoplasmic reticulum stress
steroid metabolic process
ubiquitin protein ligase binding
alcohol metabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
regulation of lipid metabolic process
regulation of small molecule metabolic process