ETV6

Gene Information

Official Symbol: ETV6
Official Name: ETS variant transcription factor 6
Aliases and Previous Symbols: N/A
Entrez ID: 2120
UniProt: P41212
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008].
UniProt Summary: Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hypoxia 5%O2 R04 exp191	-2.45
IU1-47 25μM R04 exp182	-2.28
Amiloride 100μM R08 exp447	-1.85
SGC2043 10μM R03 exp152	-1.82
Chlorpromazine 10μM R07 exp344	-1.8
Citral 50μM R06 exp274	-1.79
Chloroquine 32μM R08 exp470	1.73
Senexin-A 25μM R07 exp400	1.84
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.88

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3846
Expression level (log2 read counts): 4.96

Expression Distribution

SAM PNT
Ets

mesenchymal cell apoptotic process
vitellogenesis
cytoplasm organization
hematopoietic stem cell proliferation
stem cell proliferation
female gamete generation
protein domain specific binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II regulatory region sequence-specific DNA binding
cellular process involved in reproduction in multicellular organism
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
cell population proliferation
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
DNA-binding transcription factor activity
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
nucleolus
negative regulation of transcription by RNA polymerase II
apoptotic process
multi-organism reproductive process
programmed cell death
cell death
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
reproductive process
reproduction
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process