FANK1

Entrez Summary: N/A
UniProt Summary: Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis. {ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:27060496}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ank
Ank 2

chromatin
ciliary basal body
cilium
positive regulation of DNA-binding transcription factor activity
regulation of DNA-binding transcription factor activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
positive regulation of transcription, DNA-templated
regulation of apoptotic process
regulation of programmed cell death
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of cell death
positive regulation of RNA metabolic process
positive regulation of molecular function
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process