FGD3

Entrez Summary: N/A
UniProt Summary: Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

filopodium assembly
small GTPase binding
Rho guanyl-nucleotide exchange factor activity
ruffle
guanyl-nucleotide exchange factor activity
regulation of Rho protein signal transduction
regulation of cell shape
lamellipodium
regulation of Ras protein signal transduction
regulation of small GTPase mediated signal transduction
cytoskeleton
plasma membrane bounded cell projection assembly
cell projection assembly
regulation of GTPase activity
regulation of cell morphogenesis
actin cytoskeleton organization
actin filament-based process
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
Golgi apparatus
regulation of anatomical structure morphogenesis
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
regulation of hydrolase activity
G protein-coupled receptor signaling pathway
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
regulation of intracellular signal transduction