FPGT

Entrez Summary: N/A
UniProt Summary: Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover of glycoproteins and glycolipids.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Menadione 5μM R06 exp292	1.72
Rifampicin 10μM R00 exp32	1.74
Nocodazole 0.2μM R00 exp24	1.83
Dimethyloxaloylglycine 11μM R07 exp314	1.85
Cerivastatin 0.15μM R05 exp226	1.89
Doxycycline 10μM R00 exp18	2.46

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

fucose-1-phosphate guanylyltransferase activity
fucose metabolic process
catalytic activity
hexose metabolic process
monosaccharide metabolic process
GTP binding
carbohydrate metabolic process
small molecule metabolic process