FTSJ3

Entrez Summary: N/A
UniProt Summary: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:22195017}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.04μM R03 exp98	-1.98
Pimelic-diphenylamide-106 5μM R00 exp28	-1.83
Vitamin-D3 40μM R08 exp536	-1.76
Hydroxyurea 15μM R06 exp289	1.82
Citral 50μM R06 exp274	1.92
TGF-beta1 44ng/ml R08 exp528	2.18
39°C R06 exp303	2.31
Asunaprenir 3μM R07 exp336	2.32

Global Fraction of Cell Lines Where Essential: 19/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	4/28
bone	1/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	0/29
uterus	0/5

Expression Distribution

enzyme-directed rRNA 2-O-methylation
RNA 2-O-methyltransferase activity
rRNA (uridine-2-O-)-methyltransferase activity
rRNA (guanine) methyltransferase activity
rRNA 2-O-methylation
preribosome, small subunit precursor
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of LSU-rRNA
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
preribosome, large subunit precursor
rRNA methylation
maturation of 5.8S rRNA
rRNA modification
ribosomal large subunit biogenesis
RNA methylation
RNA modification
rRNA processing
rRNA metabolic process
macromolecule methylation
ribosome biogenesis
methylation
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
RNA metabolic process
gene expression