GSKIP

Gene Information

Official Symbol: GSKIP
Official Name: GSK3B interacting protein
Aliases and Previous Symbols: N/A
Entrez ID: 51527
UniProt: Q9P0R6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702). {ECO:0000269|PubMed:16981698, ECO:0000269|PubMed:19830702, ECO:0000269|PubMed:25920809, ECO:0000269|PubMed:27484798}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 0.001μM R08 exp429	1.75
ZLN024 50μM R08 exp538	1.8
Clomiphene 4.4μM R02 exp68	1.81
Rapamycin 2μM R07 exp306	1.86
Rapamycin 1μM R00 exp29	2.33

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18341
Expression level (log2 read counts): 3.73

Expression Distribution

Gene	Correlation
YPEL5	0.489
GSK3B	0.464
WDR26	0.449
FAM122A	0.438
MEMO1	0.415
GLYR1	0.408
PCGF1	0.406

intrinsic apoptotic signaling pathway in response to oxidative stress
cell death in response to oxidative stress
protein kinase A regulatory subunit binding
protein kinase A binding
protein kinase inhibitor activity
beta-catenin binding
positive regulation of canonical Wnt signaling pathway
intrinsic apoptotic signaling pathway
positive regulation of Wnt signaling pathway
negative regulation of protein kinase activity
cellular response to oxidative stress
negative regulation of kinase activity
negative regulation of transferase activity
regulation of canonical Wnt signaling pathway
apoptotic signaling pathway
regulation of Wnt signaling pathway
response to oxidative stress
negative regulation of protein phosphorylation
negative regulation of phosphorylation
protein kinase binding
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
apoptotic process
regulation of transferase activity
negative regulation of cellular protein metabolic process
programmed cell death
cell death
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of signal transduction
intracellular signal transduction
cellular response to stress
regulation of phosphate metabolic process
regulation of phosphorus metabolic process