GYPB
Gene Information
- Official Symbol: GYPB
- Official Name: glycophorin B (MNS blood group)
- Aliases and Previous Symbols: N/A
- Entrez ID: 2994
- UniProt: P06028
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
- UniProt Summary: This protein is a minor sialoglycoprotein in erythrocyte membranes.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14411
- Expression level (log2 read counts): -1.65
GYPB Expression in NALM6 Cells: -1.65
