HELQ

Entrez Summary: N/A
UniProt Summary: Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase (PubMed:11751861). Involved in the repair of DNA cross- links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904). {ECO:0000269|PubMed:11751861, ECO:0000269|PubMed:19995904}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Olaparib 4μM R08 exp512	-2.98
Rucaparib 6.5μM R08 exp520	-2.46
Nutlin-3A 1.6μM R06 exp294	-2.42
Diepoxybutane 3μM R07 exp354	-2.35
Talazoparib 0.006μM R06 exp299	-2.35
VE-822 0.04μM R06 exp300	-1.88
Ethanol 0.01 R05 exp234	-1.75
Asunaprenir 3μM R07 exp336	1.71
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Helicase C
DEAD

single-stranded DNA helicase activity
resolution of meiotic recombination intermediates
meiotic chromosome separation
chromosome separation
reciprocal meiotic recombination
homologous recombination
DNA helicase activity
meiotic chromosome segregation
double-strand break repair via homologous recombination
recombinational repair
meiosis I
DNA duplex unwinding
meiosis I cell cycle process
DNA geometric change
meiotic nuclear division
meiotic cell cycle process
double-strand break repair
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
chromosome segregation
nuclear division
DNA conformation change
organelle fission
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
cell cycle process
chromosome organization
cell cycle
reproductive process
reproduction
DNA binding
ATP binding
cellular response to stress